HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.
HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy.
Recombinant HuD Protein
Detection of anti-Hu paraneoplastic antibodies via Western Blot or ELISA assay.
Storage instructions Heat stable , shipped at ambient temp. Upon delivery aliquot and store in fridge , longterm storage at -20°C. Storage buffer PBS, pH 7.2 Purification notes
Expressed in E.Coli as a 6his and MBP fusion protein and purified by MBP-tag affinity chromatography
SDS gel of HuD fusion protein
10ug HuD protein
To order, please use our online cart buttons on each page. You can use Paypal or Major Credit cards.
Alternatively you can email your purchase requisition with P.O. number, catalog numbers, quantity, and shipping & billing addresses to: