HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4gene.[4][5]The HuD/ELAVL4 protein is an RNA-binding protein.[6]HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[7][8]
The 16C12 monoclonal antibody is the reagent of choice to determine the expression of HuD (ELAVL4) by IHC or western blotting. It is known to react with human, mouse, rat, and zebrafish HuD. It was generated against a unique peptide found in HuD and does not bind to HuC, HeLN-1 or HuR. The figure below shows the utility of 16C12. Click on the image to view the published paper.
Tested applications ELISA, WB , IHC
Immunogen
Synthetic peptide
Form Liquid
Storage instructions Heat stable , shipped at ambient temp Upon delivery aliquot and store in fridge , longterm storage at -20°C.
Storage buffer PBS, pH 7.2
Concentration 100 µl at 1.0 mg/ml
Clonality
Monoclonal 16C12
Isotype IgG2b
Standard 100ug
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