HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[4][5]
HuD was originall discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD can be used to ascertian AU-binding elements in mRNA , assay the presence of anti-Hu antibodies and diagnose the presence of small cell lung cancer.
Product name
HuD Protein ( AA 2-216 )
Description
The first two binding domains of HuD which encodes mRNA binding activity and is also suitable for the detection of paraneoplastic syndrome Hu antibodies.
Tested applications mRNA binding assays, assay of anti-Hu paraneoplastic antibodies, ELISA assay, WB assay. Form Liquid Storage instructions Heat stable , shipped at ambient temp. Upon delivery aliquot and store in fridge , longterm storage at -20°C. Storage buffer PBS, pH 7.2 Purification notes
Expressed in E.Coli and purified by affinity chromatography
HuD selectively binds to AU element in c-fos mRNA. EMSA assay
10ug HuD protein
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