| Anti-Dicer Mouse Monoclonal 13D6 Cat # CG006 |
Dicer is an endoribonuclease in the RNase III family that cleaves double-stranded RNA (dsRNA) and pre-microRNA (miRNA) into short double-stranded RNA fragments called small interfering RNA (siRNA) about 20-25 nucleotides
long, usually with a two-base overhang on the 3' end. Dicer contains
two RNase III domains and one PAZ domain; the distance between these two
regions of the molecule is determined by the length and angle of the
connector helix and determines the length of the siRNAs it produces.Dicer catalyzes the first step in the RNA interference pathway and initiates formation of the RNA-induced silencing complex (RISC), whose catalytic component argonaute is an endonuclease capable of degrading messenger RNA (mRNA) whose sequence is complementary to that of the siRNA guide strand. The human version of this gene is DICER1. Clonegene is the OEM of
two monoclonal antibodies against Dicer (13D6 and 4A6 ) which have both been characterized by
siRNA validation. Dicer plays a role in follicular development in ovary(see image below) .Click on image to go to original published paper which used 13D6 .
|
 |
| siRNA VALIDATION of 13D6 |
|
|
|
Raised in Mouse
Clonality Monoclonal Clone number 13D6
Isotype IgG1
Purity Protein G purified
Storage buffer Proprietary high stability buffer
Shipped at ambient temperature , long term storage -20.
Works for WB, IHC, IP , IF ,CHIP, CLIP, IHC on FFPE
Reacts with human, mouse and rat Dicer
|
|
|
