| Anti-HuR ( Monoclonal 19F12 ) cat# CG001 |
HuR (also called Elavl-1 or HuA) is a protein that
binds to specific AU-rich elements in a mRNA and thereby upregulates its
expression. The protein contains three RRM type RNA binding domains.
The first and second RNA binding domains interact with the AU-rich
element. HuR is a member of a
family of proteins called the elav-like proteins. The other members,
HuD, HuC, and HEL-N1 are predominantly expressed in neurons. Monoclonal 19F12 was designed by CLONEGENE and was generated against a unique HuR peptide and
does not react with HuD, HuC, or Hel-N1. It is ideal for western blot
and immunohistochemistry applications and has been featured in many
scientific publications.
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| IHC on FFPE ovarian tumor |
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Raised in Mouse
Clonality Clone number 19F12
Isotype IgG1
Purification notes Precipitated from tissue culture supernatant.
Storage buffer High stability buffer , shipped at ambient temperature , store at -20
Works for WB, IHC, IP , CHIP , CLIP, IHC on FFPE sections
Reacts with human, mouse, rat, xenopus, zebrafish HuR .
Other species ? Contact us and we will let you know
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The picture above is from a recent publication on the regulation of gene expression by HuR and illustrates the utility of mab 19F12. Click on the picture to go to the original paper.
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The picture above is from a 2011 publication on the merits of different approaches to RNA immunoprecipitation (RIP ) analysis and uses HuR as a positive control. Click on the picture to go to the original paper.
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