| Elav Antibody 8B3 ( RIP/CHIP grade) Cat # CG 066 |
The elav gene is the prototype for a developmental regulator encoding a tissue-specific RNA-binding protein. The family of elav-like genes includes multiple members that are expressed in the nervous system at different times during development and also one that is expressed in all tissues. The elav-like proteins are proposed to function by binding to specific mRNAs and regulating their expression to control a developmental program. Consistent with this model, the overexpression of some elav-like genes results in an alteration in the developmental fates of some cells. Potential mRNA targets for these proteins have been identified along with functions in alternative RNA processing, cytoplasmic polyadenylation, and mRNA stability. This diversity of post-transcriptional regulatory events may be due to combinatorial interactions with other RNA-binding proteins and multiple effectors of RNA regulation.
The expression of Elav proteins is a biomarker for neuronal cells, small cell lung cancers and melanomas.
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Monoclonal 8B3 was generated against a conserved peptide that is present in the neuronal specific members ( HuD, HuC, HEL-N1) of the Elav familiy. Monoclonal 8B3 works well in western blot and IHC , but was specifically selected becasue of it's abiity to supershift Elav /mRNA ribonucleoprotein complexes. Thus, it is an exellent reagent to identify mRNA targets by RIP or CLIP technologies.
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Mouse monoclonal
Clone number 8B3
Isotype IgG2b
Preparation - Purified Antibody
Transport - Shipped at ambient temperature
Storage - On arrival aliquot and store at -20, a working aliquot is stable at room temperature for weeks.
Works for WB, IHC, IP, CHIP, CLIP, RIP , IHC on FFPE sections.
Reacts with human, mouse, rat, xenopus and zebrafish Elav proteins,(HuD HuC, Hel-N1 ) .
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