| Anti-HuR Monoclonal Antibody 19F12 (CHIP grade) CG001 |
HuR (also called
Elavl-1 or HuA) is a protein that
binds to specific AU-rich elements in a mRNA and thereby upregulates its
expression. The protein contains three RRM type RNA binding domains.
The first and second RNA binding domains interact with the AU-rich
element. HuR is a member of a
family of proteins called the elav-like proteins. The other members,
HuD, HuC, and HEL-N1 are predominantly expressed in neurons. Monoclonal
19F12 was designed by CLONEGENE and was generated against a unique HuR
peptide and
does not react with HuD, HuC, or Hel-N1.
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The picture above shows HuR expression using 19F12 on a FFPE section and the paper indicates that it is a prognostic factor in Invasive Ductal Breast Carcinoma. Click on the picture to access the paper.
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The picture above is from a recent publication on the regulation of gene expression by HuR and illustrates the utility of mab 19F12. Click on the picture to go to the original paper.
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The picture above is from a 2011 publication on the merits of different approaches to RNA immunoprecipitation (RIP ) analysis and uses HuR as a positive control. Click on the picture to go to the original paper.
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