| Anti-HuR mouse monoclonal antibody 4C8 - Cat# CG0098 |
HuR (also called Elavl-1 or HuA) is an RNA binding protein that binds to specific AU-rich elements in a mRNA and thereby upregulates its expression. The protein contains three RRM type RNA binding domains. The first and second RNA binding domains interact with the AU-rich element. HuR is a member of a family of proteins called the elav-like proteins. The other members, HuD, HuC, and HEL-N1 are predominantly expressed in neurons. Monoclonal 4C8 was designed by CLONEGENE and was generated against a unique HuR peptide and does not react with HuD, HuC, or Hel-N1. Monoclonal 4C8 works well in western blot and IHC , but was specifically selected becasue of it's abiity to supershift HuR/mRNA ribonucleoprotein complexes. In the figue shown , the HuR/MRNA complex ( Lane 1) is significanlty supershifted ( Lane 2) by the addition of 10ng of 4C8. Thus, this is the ideal reagent for RNA immunoporecipitation studeies.
Mouse monoclonal
Clone number 4C8
Isotype IgG1
Purified Antibody
Aliquot and store at -20 , stable at ambient temperature for months.
Works for WB, IHC, IP, CHIP, CLIP, IHC on FFPE sections.
Reacts with human, mouse, rat, xenopus and zebrafish HuR.
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| Supershift of HuR complex |
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