HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[4][5]
HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy. In normal cells , it functions to regulate gene expression and the recombinant protein has been used to identify regualtory elements in mRNA.
Product name
Recombinant HuD Protein
Tested applications
Detection of anti-Hu paraneoplastic antibodies via WB or ELISA assay. Identification of regulatory elements in mRNA. Form Liquid Storage instructions Heat stable , shipped at ambient temp. Upon delivery aliquot and store in fridge , longterm storage at -20°C. Storage buffer PBS, pH 7.2 Purification notes
Expressed in E.Coli and purified by affinity chromatography
HuD selectively binds to AU element in c-fos mRNA. EMSA assay
SDS Gel analysis of recombinant HuD
10ug HuD protein
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