CG 0137 Mouse Monoclonal 13E7 to TIGIT, VSTM3, WUCAM (T cell immunoreceptor with Ig and ITIM domains)
TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK).[1] It is also identified as WUCAM[2] and Vstm3.[3] TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity.[1]
Research has shown that TIGIT-Fc fusion protein could interact with PVR on dendritic cells and increase its IL-10 secretion level/decrease its IL-12 secretion level under LPS stimulation, and also inhibit T cell activation in vivo.[1] TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain[4]
Product name
Anti-TIGIT
Description
Mouse Monoclonal to TIGIT
Tested applications ELISA, WB , IHC
Immunogen
TIGIT
Form Liquid
Storage instructions Heat stable , shipped at ambient temp Upon delivery aliquot and store in fridge , longterm storage at -20°C.
Storage buffer PBS, pH 7.2
Concentration 100 µl at 1.0 mg/ml
Purification notes
Purified from hybridoma supernatant
Clonality
Monoclonal 13E7
Isotype IgG1
IHC on mouse spleen
Standard Size
100ug
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