PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells).[3][4]
A new class of drugs that block PD-1, the PD-1 inhibitors, activate the immune system to attack tumors and are therefore used to treat cancer.[5]
Product name
Anti-PD-1
Description A high affinity mouse monoclonal against human PD-1 (CD279)
Tested applications
ELISA, WB, IHC, FFPE, IHC
Immunogen
Native PD-1 protein
Form Liquid
Storage instructions Heat stable , shipped at ambient temp Upon delivery aliquot and store in fridge , longterm storage at -20°C.