PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells).[3][4]
A new class of drugs that block PD-1, the PD-1 inhibitors, activate the immune system to attack tumors and are therefore used to treat cancer.[5]
18B2 is a new high affinity mouse monoclonal ( IgG1) directed against PD-1
Product name
Anti- PD-1 Mab 18B2
Description A high affinity mouse monoclonal against human PD-1 (CD279)
Tested applications
ELISA, WB, IHC, FFPE IHC
Immunogen
Native PD-1 protein
Form Liquid
Storage instructions Heat stable , shipped at ambient temp Upon delivery aliquot and store in fridge , longterm storage at -20°C.
Storage buffer PBS, pH 7.2
Concentration 100 µl at 1.0 mg/ml
Purification notes
Purified from hybridoma supernatant
Clonality Monoclonal 18B2
Isotype
IgG1
A w.t. B PD1 ko
Standard Size
NEXT DAY DELIVERY
on orders before 4pm EST
Sample Size
20ug 50$
INTERNATIONAL DELIVERY
To order, please use our online cart buttons on each page. You can use Paypal or Major Credit cards.
Alternatively you can email your purchase requisition with P.O. number, catalog numbers, quantity, and shipping & billing addresses to:
