HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[4][5]
HuD was originaly discovered as the paraneoplastic neoantigen expressed in neuroendocrine tumors. Recombinant HuD can be used in RNA biology studies, to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and to formulate novel Neoantigen cancer vaccines.
Product name
Recombinant HuD Protein
Description
The first two binding domains of HuD.
Tested applications Detection of anti-Hu paraneoplastic antibodies via WB or ELISA assay. Identification of regulatory elements in mRNA. Form Liquid Storage instructions Heat stable , shipped at ambient temp. Upon delivery aliquot and store in fridge , longterm storage at -20°C. Storage buffer PBS, pH 7.2 Purification notes
Expressed in E.Coli and purified by affinity chromatography
HuD selectively binds to AU element in c-fos mRNA. EMSA assay
SDS Gel analysis of recombinant HuD
10ug HuD protein
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