Dicer is an endoribonuclease in the RNase III family that cleavesdouble-stranded RNA (dsRNA) and pre-microRNA (miRNA) into short double-stranded RNA fragments called small interfering RNA (siRNA) about 20-25nucleotides long, usually with a two-base overhang on the 3' end. Dicer contains two RNase III domains and one PAZ domain; the distance between these two regions of the molecule is determined by the length and angle of the connector helix and determines the length of the siRNAs it produces.Dicer catalyzes the first step in the RNA interference pathway and initiates formation of the RNA-induced silencing complex (RISC), whose catalytic component argonaute is an endonuclease capable of degrading messenger RNA(mRNA) whose sequence is complementary to that of the siRNA guide strand. The human version of this gene isDICER1.
Monoclonal 13D6 is the classic antibody for the analysis of Dicer .
Product name
Anti-Dicer
Description
Classic Antibody
Tested applications WB , IHC, IP, IHC on FFPE, ChIP
Immunogen
Synthetic peptide
Form Liquid-Hybridoma supernatant
Storage instructions Heat stable , shipped at ambient temp Upon delivery aliquot and store in fridge , longterm storage at -20°C.
Storage buffer PBS, pH 7.2
Clonality
Monoclonal 13D6
Isotype
IgG1
Standard Package
100ul Hybridoma Supernatant
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