Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers,[15]glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).[16] These somatic mutations involving EGFR lead to its constant activation, which produces uncontrolled cell division.[17] In glioblastoma a more or less specific mutation of EGFR, called EGFRvIII is often observed.[18] Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers.
Anti-EGFR Mouse Monoclonal 225 is a classic reagent in cancer research with more than 100 published references.
Name
Anti-EGFR mab 225
Reactivity
Humam, mouse, rat.
Tested applications IHC, WB, Flow, neutralization of EGFR signalling
Immunogen
EGFR
Form Liquid
Storage instructions Heat stable , shipped at ambient temp Upon delivery aliquot and store in fridge , long term storage at -20°C.
Storage buffer PBS, pH 7.2
Purification notes
Purified via protein G
Clonality
Mouse monoclonal 225
Isotype
Mouse IgG1
100ug of Anti-EGFR Mab 225
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