Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers,[15]glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).[16] These somatic mutations involving EGFR lead to its constant activation, which produces uncontrolled cell division.[17] In glioblastoma a more or less specific mutation of EGFR, called EGFRvIII is often observed.[18] Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers.
Cetuximab ( Mab C225) is the humanized version of the mouse mab 225 and has been well charaterized in therapeutic and research arenas.
Name
Cetuxiab(Anti-EGFR mab C225)
Reactivity
Humam, mouse, rat.
Tested applications IHC, WB, Flow, neutralization of EGFR signalling
Immunogen
EGFR
Form Liquid
Storage instructions Heat stable , shipped at ambient temp Upon delivery aliquot and store in fridge , long term storage at -20°C.
Storage buffer PBS, pH 7.2
Purification notes
Purified via protein G
Clonality
Humanized Mouse monoclonal C225
Isotype
Human IgG1
100ug of Cetuximab Mab C225
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